Description

13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-19-Demethyl-N1-[3-(Dimethylamino)Propyl]-12-Hydroxybleomycinamide CAS NO 77368-74-2 is a structurally complex bleomycin derivative, a class of glycopeptide antibiotics known for their potent antitumor activity. This compound is of significant interest in pharmaceutical research and development due to its mechanism of action involving DNA cleavage. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel chemotherapeutic agents and the study of antibiotic mechanisms.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of new bleomycin-based anticancer drugs.
• Oncology Drug Discovery: Used in biochemical and cellular assays to investigate DNA interaction, cytotoxicity, and mechanisms of action against various cancer cell lines.
• Antibiotic Mechanism Studies: Employed as a tool compound to explore the structure-activity relationships (SAR) within the bleomycin family of glycopeptide antibiotics.
• Biochemical Reagent: Acts as a specialized reagent in laboratories focusing on molecular biology and DNA damage research.
• Reference Standard: Used for analytical purposes, including method development, validation, and quality control (QC) in pharmaceutical manufacturing of related compounds.

Basic Information

Product Name	13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-19-Demethyl-N1-[3-(Dimethylamino)Propyl]-12-Hydroxybleomycinamide
CAS No.	77368-74-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	19-Demethyl-N1-[3-(dimethylamino)propyl]-12-hydroxybleomycinamide, 13-[(4-amino-4,6-dideoxy-α-L-talopyranosyl)oxy]-; Bleomycin derivative; Talisomycin derivative; BLM derivative; Antibiotic 77368-74-2; Pharmaceutical Intermediate 77368-74-2
EINECS	Contact for details

Quality Control

Our 13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-19-Demethyl-N1-[3-(Dimethylamino)Propyl]-12-Hydroxybleomycinamide is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), identification, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.