Description

13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-N1-(3-Aminopropyl)-19-Demethyl-12-Hydroxybleomycinamide is a structurally complex, semi-synthetic derivative of the bleomycin family of glycopeptide antibiotics. This compound is valued for its potent mechanism of action, which involves sequence-selective cleavage of DNA, making it a critical intermediate and research tool in oncology and molecular biology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and manufacturers of active pharmaceutical ingredients (APIs) focused on developing novel chemotherapeutic agents and studying DNA-protein interactions.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of next-generation bleomycin-based chemotherapeutic agents.
• Biochemical Research: Used as a precise tool to induce DNA strand breaks in studies of DNA repair mechanisms, chromatin structure, and genomic instability.
• Antitumor Agent Development: Investigated for its efficacy and reduced pulmonary toxicity profile compared to parent bleomycin compounds in preclinical cancer models.
• Molecular Biology Reagent: Employed in vitro to create defined DNA cleavage patterns for mapping and sequencing applications.
• API Manufacturing: Incorporated into GMP-compliant synthesis pathways for specialized oncology drugs under development.
• Mechanistic Studies: Facilitates research into the structure-activity relationships (SAR) of glycopeptide antibiotics to design molecules with improved therapeutic indices.

Basic Information

Item	Details
Product Name	13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-N1-(3-Aminopropyl)-19-Demethyl-12-Hydroxybleomycinamide
CAS No.	77368-73-1
Molecular Formula	C57H89N19O21S2
Molecular Weight	~1420.56 g/mol
Synonyms	19-Demethyl-12-hydroxybleomycinamide derivative; Talisomycin S10b derivative; Bleomycin A2 analog; 13-[(4-Amino-4,6-dideoxy-α-L-talopyranosyl)oxy]-N1-(3-aminopropyl)-19-demethyl-12-hydroxybleomycinamide; BLM derivative; 77368-73-1; Antibiotic BLM intermediate
EINECS	Contact for details

Quality Control

Our production of this high-purity biochemical adheres to stringent quality protocols suitable for research and pharmaceutical development. Each batch is characterized using advanced analytical techniques including HPLC for purity and identity confirmation. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications for assay, related substances, and residual solvents. We support development projects requiring material manufactured under GMP-like conditions and can tailor purity grades to meet specific research or pre-clinical application needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.