Description

13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-N1-(2-Aminoethyl)-19-Demethyl-12-Hydroxybleomycinamide is a sophisticated bleomycin derivative, representing a key intermediate in the development of novel antitumor agents. This compound is of significant interest for its role in pharmaceutical research, particularly in the study of structure-activity relationships to enhance therapeutic efficacy and reduce side effects. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology drug discovery and the synthesis of next-generation chemotherapeutic candidates.

Application

• Pharmaceutical Research Intermediate: A critical building block for the synthesis and structural modification of bleomycin-based anticancer drugs.
• Oncology Drug Discovery: Used in preclinical studies to investigate new mechanisms of action and improve the selectivity of antitumor compounds.
• Biochemical Research: Serves as a tool compound for studying DNA cleavage and the biological pathways of glycopeptide antibiotics.
• API Development: Employed in the development and scale-up processes for Active Pharmaceutical Ingredients (APIs) targeting solid tumors.
• Academic Research: Utilized in university and institutional labs for chemical biology and medicinal chemistry projects.

Basic Information

Product Name	13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-N1-(2-Aminoethyl)-19-Demethyl-12-Hydroxybleomycinamide
CAS No.	77368-72-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	19-Demethyl-12-hydroxybleomycinamide derivative; Bleomycin A2 derivative; Talopyranosyl bleomycinamide; 13-O-(4-Amino-4,6-dideoxy-α-L-talopyranosyl)-N1-(2-aminoethyl)-19-demethyl-12-hydroxybleomycinamide; BLM derivative; Glycopeptide antibiotic intermediate; Antitumor antibiotic intermediate
EINECS	Contact for details

Quality Control

Our 13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-N1-(2-Aminoethyl)-19-Demethyl-12-Hydroxybleomycinamide is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) or as specified on the label or COA. This product is light-sensitive and easily oxidized; prolonged exposure to air, light, or moisture should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.