Description

13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-N1-[4-Amino-6-[[3-(Dimethylsulfonio)Propyl]Amino]-6-Oxohexyl]-19-Demethyl-12-Hydroxybleomycinamide is a structurally complex bleomycin derivative, representing a key intermediate in advanced pharmaceutical research and development. This compound matters for its role in the synthesis and study of novel antitumor agents, offering researchers a precise tool for investigating structure-activity relationships and developing next-generation chemotherapeutics. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on oncology drug discovery and high-purity active pharmaceutical ingredient (API) synthesis.

Application

• Pharmaceutical Intermediate: Critical building block in the synthetic pathway for novel bleomycin-based antitumor agents and antibiotic derivatives.
• Oncology Research: Used as a reference standard and precursor in biochemical and pharmacological studies targeting DNA cleavage and cancer cell cytotoxicity.
• Mechanistic Studies: Employed to investigate the mode of action, metal-binding properties, and cellular uptake mechanisms of bleomycin-family compounds.
• API Development: Serves as a key starting material (KSM) or advanced intermediate in the development and scale-up of potential therapeutic candidates.
• Analytical Standard: Utilized as a high-purity certified reference material (CRM) for quality control and method validation in analytical laboratories.
• Bioconjugation Research: Provides a functionalized scaffold for developing antibody-drug conjugates (ADCs) or other targeted drug delivery systems.

Basic Information

Product Name	13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-N1-[4-Amino-6-[[3-(Dimethylsulfonio)Propyl]Amino]-6-Oxohexyl]-19-Demethyl-12-Hydroxybleomycinamide
CAS No.	77368-65-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	19-Demethyl-12-hydroxybleomycinamide derivative; Bleomycin A2 derivative; BLM derivative; Talopyranosyl bleomycinamide; 77368-65-1; (4-Amino-4,6-dideoxy-α-L-talopyranosyl)oxy bleomycin analog; N1-[4-Amino-6-[[3-(dimethylsulfonio)propyl]amino]-6-oxohexyl]bleomycinamide
EINECS	Contact for details

Quality Control

Our 13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-N1-[4-Amino-6-[[3-(Dimethylsulfonio)Propyl]Amino]-6-Oxohexyl]-19-Demethyl-12-Hydroxybleomycinamide is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing batch-specific results are available upon request, supporting compliance with internal specifications and research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.