Description

13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-N1-[4-Amino-6-[[3-[(2-Hydroxyethyl)Amino]Propyl]Amino]-6-Oxohexyl]-19-Demethyl-12-Hydroxybleomycinamide is a structurally complex, semi-synthetic derivative of the bleomycin family of glycopeptide antibiotics. This compound is of significant interest for its potential to offer modified pharmacological profiles, including altered DNA-binding affinity and reduced pulmonary toxicity compared to parent compounds. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of next-generation anticancer therapeutics and for advanced biochemical research.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the research and synthesis of novel antitumor agents and antibiotic derivatives.
• Oncology Research: Used in biochemical and pharmacological studies to investigate mechanisms of action, structure-activity relationships (SAR), and cytotoxicity against various cancer cell lines.
• Molecular Biology Tool: Employed as a research-grade chemical for studying DNA cleavage, repair mechanisms, and genomic instability.
• API Development: Investigated as a potential active pharmaceutical ingredient (API) or precursor in the development of new chemotherapeutic formulations.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.

Basic Information

Product Name	13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-N1-[4-Amino-6-[[3-[(2-Hydroxyethyl)Amino]Propyl]Amino]-6-Oxohexyl]-19-Demethyl-12-Hydroxybleomycinamide
CAS No.	77368-64-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	19-Demethyl-12-hydroxybleomycinamide derivative; Talopyranosyl bleomycin derivative; Bleomycin A2 analog; Modified bleomycin; 77368-64-0; BLM derivative; Glycopeptide antibiotic intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment. We support development projects requiring compliance with ICH guidelines and can tailor specifications to meet specific research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccated environment to maintain stability and prevent degradation. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Total Impurities	≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.