Description

N1-[4-Amino-6-[(3-Aminopropyl)Amino]-6-Oxohexyl]-13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-19-Demethyl-12-Hydroxybleomycinamide CAS NO 77368-63-9 is a structurally complex, semi-synthetic derivative of the bleomycin family of glycopeptide antibiotics. This compound is of significant interest for its potential in advanced pharmaceutical research, particularly in the development of novel chemotherapeutic agents and as a biochemical tool. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology drug discovery, mechanism of action studies, and the synthesis of targeted anti-cancer conjugates.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of next-generation bleomycin analogs for cancer therapy research.
• Biochemical Research: Used as a precise molecular tool to study DNA cleavage mechanisms and the structure-activity relationships (SAR) of glycopeptide antibiotics.
• Oncology Drug Discovery: Integral in the development and screening of novel chemotherapeutic candidates targeting specific cellular pathways.
• Antitumor Agent Development: Employed in the research of conjugates and prodrugs designed for improved tumor targeting and reduced systemic toxicity.
• Academic Research: Utilized in university and institutional labs for fundamental studies in medicinal chemistry and molecular biology.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	N1-[4-Amino-6-[(3-Aminopropyl)Amino]-6-Oxohexyl]-13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-19-Demethyl-12-Hydroxybleomycinamide
CAS No.	77368-63-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Bleomycinamide derivative; 19-Demethyl-12-hydroxybleomycinamide analog; Talopyranosyl bleomycin derivative; 6-Oxohexyl bleomycinamide; Aminoalkyl bleomycin conjugate; Bleomycin A2 derivative; Research Compound 77368-63-9
EINECS	Contact for details

Quality Control

Our N1-[4-Amino-6-[(3-Aminopropyl)Amino]-6-Oxohexyl]-13-[(4-Amino-4,6-Dideoxy-α-L-Talopyranosyl)Oxy]-19-Demethyl-12-Hydroxybleomycinamide is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. All materials are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support pre-clinical and development-phase pharmaceutical needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere or with appropriate desiccants to prevent degradation. For long-term stability, consider storage at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.