Description

3-Fluoro-4-(Trimethylsilyl)Pyridine is a high-value organosilicon building block featuring a pyridine ring substituted with both fluorine and a trimethylsilyl group. This unique structure makes it a versatile intermediate for synthesizing complex molecules in advanced research and development. It is particularly valuable for pharmaceutical chemists and agrochemical researchers seeking to introduce fluorine and silicon functionalities to modulate the biological activity and physicochemical properties of lead compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, where the fluorine atom can enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic electronic materials.
• Chemical Biology Probes: Useful for creating tagged molecules and probes for studying biological systems and enzyme mechanisms.
• Cross-Coupling Reactions: The trimethylsilyl group can act as a masked functional handle for further derivatization via protodesilylation or cross-coupling.

Basic Information

Product Name	3-Fluoro-4-(Trimethylsilyl)Pyridine
CAS No.	77332-77-5
Molecular Formula	C8H12FNSi
Molecular Weight	169.27 g/mol
Synonyms	4-(Trimethylsilyl)-3-fluoropyridine; 3-Fluoro-4-trimethylsilylpyridine; Pyridine, 3-fluoro-4-(trimethylsilyl)-; 3-Fluoro-4-(TMS)pyridine; 3-Fluoro-4-pyridyltrimethylsilane
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-(Trimethylsilyl)Pyridine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP standards for advanced intermediate production, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.