Description

5-Iminodoxorubicin is a chemically modified derivative of the potent anthracycline antibiotic, doxorubicin. This compound is of significant interest in pharmaceutical research and development due to its structural relationship to a widely used chemotherapeutic agent. It serves as a critical intermediate and reference standard for researchers in oncology, pharmacology, and medicinal chemistry. The product is essential for studies focused on drug metabolism, mechanism of action, and the synthesis of novel anticancer agents.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of novel anthracycline-based chemotherapeutic agents.
• Biochemical Research: Used as a reference standard in studies investigating the structure-activity relationships (SAR) of doxorubicin analogs.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research to understand the biotransformation of anthracycline drugs.
• Mechanistic Probes: Utilized in laboratory settings to probe the biological mechanisms of topoisomerase II inhibition and DNA intercalation.
• Analytical Standard: Acts as a high-purity calibrant for analytical methods such as HPLC and LC-MS in quality control and research laboratories.
• Medicinal Chemistry: Provides a core scaffold for the design and synthesis of new chemical entities with potential antitumor activity.

Basic Information

Product Name	5-Iminodoxorubicin
CAS No.	77331-69-2
Molecular Formula	C₂₇H₂₉NO₁₁
Molecular Weight	543.52 g/mol
Synonyms	5-Imino-14-hydroxydaunomycin; 5-Imino-DOX; 5-Iminodaunorubicin; 5-IDX; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione 5-imine; AD 198 derivative; Iminodoxorubicin Hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Every batch of 5-Iminodoxorubicin is manufactured and tested under strict quality management protocols to ensure identity, purity, and consistency. We provide comprehensive analytical data, including HPLC purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis. A Certificate of Analysis (COA) detailing all test results and specifications is supplied with each shipment. Our quality systems are designed to support research and development requiring materials of the highest integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F), in a dry environment. For long-term storage, consider storing at -20°C under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.