Description

4-Demethoxy-11-Deoxyadriamycin is a synthetic anthracycline derivative and a key intermediate in the development of novel chemotherapeutic agents. This compound is valued for its role in pharmaceutical research, particularly in the synthesis and structure-activity relationship (SAR) studies of more potent and less cardiotoxic anticancer drugs. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on oncology drug discovery and development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel anthracycline-based chemotherapeutic agents.
• Oncology Research: Used in biochemical and pharmacological studies to investigate mechanisms of action and improve therapeutic indices of anticancer drugs.
• Structure-Activity Relationship (SAR) Studies: Essential for modifying the anthracycline core to develop derivatives with enhanced efficacy and reduced side effects.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Academic Research: Employed in university and institutional labs for fundamental research on DNA intercalation and topoisomerase inhibition.

Basic Information

Product Name	4-Demethoxy-11-Deoxyadriamycin
CAS No.	77312-69-7
Molecular Formula	C₂₆H₂₉NO₉
Molecular Weight	499.51 g/mol
Synonyms	4-DM-11-DA; 4-Demethoxy-11-deoxydoxorubicin; 11-Deoxy-4-demethoxydaunorubicin; 4-Demethoxy-11-deoxyadriamycin; 4-Demethoxy-11-deoxydaunorubicin; 4-Demethoxy-11-deoxydoxorubicin hydrochloride (salt form); ID-6105 (research code); 4-Demethoxy-11-deoxy-13-dihydrodaunorubicin
EINECS	Contact for details

Quality Control

Our 4-Demethoxy-11-Deoxyadriamycin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reliable and reproducible results in your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.