Description

4-Demethoxy-11-Deoxydaunomycin is a key synthetic anthracycline derivative, structurally related to the potent chemotherapeutic agents daunorubicin and doxorubicin. This compound is valued for its role as a critical intermediate in pharmaceutical research and development, enabling the synthesis of novel anticancer agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on oncology drug discovery and advanced chemical synthesis.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel anthracycline-based chemotherapeutic agents and analogs.
• Oncology Research: Used in biochemical and pharmacological studies to investigate structure-activity relationships (SAR) and mechanisms of action of anthracycline drugs.
• Reference Standard: Employed as a high-purity analytical standard in quality control (QC) and research laboratory settings for method development and validation.
• Academic Research: Utilized in university and institutional labs for studying DNA intercalation, topoisomerase II inhibition, and the development of drug resistance mechanisms.
• Fine Chemical Synthesis: Acts as a specialized precursor for the custom synthesis of labeled compounds (e.g., deuterated, fluorinated) for advanced research applications.

Basic Information

Product Name	4-Demethoxy-11-Deoxydaunomycin
CAS No.	77312-66-4
Molecular Formula	C₂₆H₂₉NO₉
Molecular Weight	499.51 g/mol
Synonyms	11-Deoxy-4-demethoxydaunomycin; 4-Demethoxy-11-deoxydaunorubicin; 4-DM-11-DX-DNR; 4-Demethoxy-11-deoxydaunorubicin hydrochloride (if applicable); Daunomycinone, 4-demethoxy-11-deoxy-; (7S,9S)-9-Acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione (IUPAC); 4-DM-11-DXD
EINECS	Contact for details

Quality Control

Our 4-Demethoxy-11-Deoxydaunomycin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The material is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on dried basis)
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.