Description

Benzene, 1-Fluoro-4-Nitro-2-[2-(Trimethylsilyl)Ethynyl]- is a high-value, multi-functional aromatic building block featuring a unique combination of a nitro group, a fluorine substituent, and a protected ethynyl (trimethylsilyl acetylene) moiety. This compound is critical for advanced organic synthesis, enabling the construction of complex molecular architectures through cross-coupling and cycloaddition reactions. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic rings or acetylene linkers for targeted drug delivery.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides, where the fluorine atom and nitro group can enhance biological activity and stability.
• Material Science Research: Acts as a monomer or building block for developing advanced polymers, liquid crystals, and organic electronic materials due to its conjugated acetylene unit and electron-withdrawing groups.
• Cross-Coupling Reactions: The trimethylsilyl-protected acetylene group is a versatile handle for Sonogashira and other palladium-catalyzed coupling reactions to form extended conjugated systems.
• Fluorine Chemistry Studies: An important compound for investigating structure-activity relationships (SAR) in medicinal chemistry and the effects of fluorine substitution on aromatic systems.
• Chemical Synthesis Reagent: Employed in academic and industrial laboratories for the preparation of complex heterocycles and functionalized arenes via nitro group reduction or displacement.

Basic Information

Item	Details
Product Name	Benzene, 1-Fluoro-4-Nitro-2-[2-(Trimethylsilyl)Ethynyl]-
CAS No.	77123-61-6
Molecular Formula	C11H12FNO2Si
Molecular Weight	237.31 g/mol
Synonyms	1-Fluoro-4-nitro-2-[(trimethylsilyl)ethynyl]benzene; 2-[(Trimethylsilyl)ethynyl]-1-fluoro-4-nitrobenzene; 4-Fluoro-3-nitro(phenylethynyl)trimethylsilane; 3-Nitro-4-fluoro(phenylethynyl)trimethylsilane; TMS-protected 2-ethynyl-4-fluoronitrobenzene; (2-Fluoro-5-nitrophenyl)ethynyltrimethylsilane; 1-Ethynyl-2-fluoro-5-nitrobenzene, trimethylsilyl derivative
EINECS	Contact for details

Quality Control

Our Benzene, 1-Fluoro-4-Nitro-2-[2-(Trimethylsilyl)Ethynyl]- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.