Description

5-Amino-2-Fluorobenzonitrile is a versatile aromatic nitrile building block characterized by its amino and fluorine substituents. This compound is highly valued in advanced organic synthesis for its dual functionality, which enables selective derivatization and the construction of complex heterocyclic systems. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing fluorinated benzimidazole or quinazoline cores.
• Agrochemical Synthesis: Used in the development of modern herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, dyes, and liquid crystals.
• Organic Light-Emitting Diodes (OLEDs): Employed in the research and development of electron-transport materials and emissive layer components.
• Chemical Biology & Proteomics: Utilized as a scaffold for designing molecular probes, enzyme inhibitors, and bioconjugation reagents.
• Academic & Contract Research: A valuable reagent for methodological studies in cross-coupling, cyanation, and fluorination chemistry.

Basic Information

Product Name	5-Amino-2-Fluorobenzonitrile
CAS No.	77123-60-5
Molecular Formula	C7H5FN2
Molecular Weight	136.13 g/mol
Synonyms	2-Fluoro-5-aminobenzonitrile; 2-Fluoro-5-cyanobenzenamine; 5-Cyano-2-fluoroaniline; 2-Fluoro-5-aminobenzene carbonitrile; Benzonitrile, 5-amino-2-fluoro-; 5-Amino-2-fluorophenyl cyanide; 2-Fluoro-5-aminophenyl cyanide
EINECS	Contact for details

Quality Control

Our 5-Amino-2-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Light yellow to beige crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	95 - 100 °C
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.