Description

4'-o-Methyldoxorubicin is a chemically modified derivative of the potent anthracycline antibiotic, doxorubicin. This analog is of significant interest in pharmaceutical research for its potential to modulate the therapeutic profile and reduce the cardiotoxicity associated with the parent compound. It is primarily utilized by research institutions and pharmaceutical developers engaged in the synthesis and evaluation of novel anticancer agents and prodrugs.

Application

• Pharmaceutical Intermediate: Key building block in the research and development of novel anthracycline-based chemotherapeutic agents.
• Oncology Research: Used as a reference standard or active compound in preclinical studies to investigate structure-activity relationships (SAR) and mechanisms of action.
• Prodrug Development: Serves as a precursor molecule for creating targeted or activated prodrugs designed to improve tumor selectivity.
• Biochemical Research: Employed in studies focusing on DNA intercalation, topoisomerase II inhibition, and cellular apoptosis pathways.
• Analytical Standard: Used in analytical laboratories for method development, validation, and quality control (HPLC, LC-MS) of related compounds.

Basic Information

Product Name	4'-o-Methyldoxorubicin
CAS No.	77121-90-5
Molecular Formula	C₂₈H₃₁NO₁₁
Molecular Weight	557.55 g/mol
Synonyms	4'-O-Methyldoxorubicin; 4'-O-Methyladriamycin; 4'-O-Methyl DOX; 4'-O-Methyl-14-hydroxydaunomycin; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; Doxorubicin 4'-methyl ether
EINECS	Contact for details

Quality Control

Our 4'-o-Methyldoxorubicin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods (NMR, MS) for structural confirmation, to ensure it meets high-purity research standards. A detailed Certificate of Analysis (COA) specifying batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.