Description

Methylprednisolone 17-Hemisuccinate is a key pharmaceutical intermediate and prodrug form of the potent corticosteroid methylprednisolone. This compound is critically important for enhancing the solubility and bioavailability of the active drug, enabling its formulation into injectable and other advanced delivery systems. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of high-potency anti-inflammatory and immunosuppressive medications.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of injectable methylprednisolone sodium succinate (Solu-Medrol®).
• Prodrug Formulation: Serves as a prodrug that is readily hydrolyzed in vivo to release the active methylprednisolone.
• Anti-inflammatory Drug Manufacturing: Essential raw material for producing corticosteroids used to treat severe allergies, inflammation, and autoimmune conditions.
• Research & Development: Used in preclinical and clinical research for studying corticosteroid metabolism and developing new therapeutic formulations.
• Hospital Pharmacy Compounding: May be utilized in specialized compounding for tailored patient treatments where commercial formulations are unsuitable.
• Veterinary Pharmaceuticals: Applied in the formulation of potent anti-inflammatory treatments for animals.

Basic Information

Product Name	Methylprednisolone 17-Hemisuccinate
CAS No.	77074-42-1
Molecular Formula	C26H34O8
Molecular Weight	474.55 g/mol
Synonyms	Methylprednisolone 21-Hemisuccinate; Methylprednisolone Hemisuccinate; 11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 17-hemisuccinate; U-67590A; Medrate-17-hemisuccinate; 6α-Methylprednisolone 17-hemisuccinate; Methylprednisolone hydrogen succinate
EINECS	Contact for details

Quality Control

Our Methylprednisolone 17-Hemisuccinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for assay and related substances, to ensure it meets high-purity standards suitable for pharmaceutical use. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.