Description

(S)-4-Hydroxy Propranolol CAS NO 76792-96-6 is a high-purity chiral metabolite and synthetic intermediate of the widely used β-blocker, propranolol. This compound is of significant value for pharmaceutical research and development, particularly in the study of drug metabolism, stereoselective pharmacokinetics, and the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in cardiovascular drug discovery and analytical method development.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of propranolol and its metabolites in bioanalytical studies, clinical trials, and quality control laboratories.
• Metabolite Research: Critical for investigating the metabolic pathways, pharmacological activity, and potential toxicity of the 4-hydroxy metabolite of propranolol in preclinical and clinical research.
• Chiral Synthesis Building Block: Serves as a key chiral intermediate in the asymmetric synthesis of more complex β-adrenergic blocking agents or related pharmacologically active molecules.
• Analytical Method Development: Employed to develop and validate sensitive HPLC, LC-MS, or GC-MS methods for the stereospecific analysis of drug substances and biological samples.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Essential for studies aiming to understand the stereoselective disposition, efficacy, and side-effect profiles of propranolol enantiomers.

Basic Information

Product Name	(S)-4-Hydroxy Propranolol
CAS No.	76792-96-6
Molecular Formula	C₁₆H₂₁NO₃
Molecular Weight	275.35 g/mol
Synonyms	(S)-4'-Hydroxypropranolol; (S)-1-Isopropylamino-3-(4-hydroxyphenoxy)-2-propanol; 4-Hydroxy-(S)-propranolol; (S)-1-(Isopropylamino)-3-(4-hydroxyphenoxy)-2-propanol; 4-Hydroxypropranolol (S-enantiomer); (S)-4-OH-Propranolol; LY 141894 (S-enantiomer); Propranolol metabolite 4-OH (S-form)
EINECS	Contact for details

Quality Control

Our (S)-4-Hydroxy Propranolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and chiral excess is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (S-enantiomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.