Description

Ala-Leu-Ala-Leu Daunorubicin Hydrochloride is a synthetic peptide-conjugated derivative of the potent anthracycline antibiotic, daunorubicin. This compound is engineered to enhance targeted delivery and therapeutic efficacy, making it a critical intermediate in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies focused on oncology drug discovery, targeted chemotherapy, and novel prodrug synthesis.

Application

• Oncology Research & Drug Discovery: Serves as a key intermediate in the development of novel, targeted chemotherapeutic agents and antibody-drug conjugates (ADCs).
• Prodrug Synthesis: Used in the design and synthesis of peptide-linked prodrugs intended for site-specific activation to minimize systemic toxicity.
• Bioconjugation Studies: Employed in research exploring the linkage of cytotoxic agents to various carriers like peptides, antibodies, or polymers.
• Mechanistic Studies: Utilized in biochemical and pharmacological research to study the structure-activity relationships (SAR) of modified anthracyclines.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Ala-Leu-Ala-Leu Daunorubicin Hydrochloride
CAS No.	76582-70-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	L-Alanyl-L-leucyl-L-alanyl-L-leucyldaunorubicin hydrochloride; Daunorubicin-ALA-LEU-ALA-LEU conjugate; Tetrapeptide-daunorubicin conjugate; ALA-LEU-ALA-LEU-DNR HCl; Peptide-linked daunorubicin; Targeted daunorubicin derivative; Daunorubicin prodrug intermediate
EINECS	Contact for details

Quality Control

Our Ala-Leu-Ala-Leu Daunorubicin Hydrochloride is manufactured under strict quality systems suitable for research and development applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and reliability. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and other critical parameters is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability.

Specification

Item	Specification
Appearance	Red to orange-red powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.