Description

4-o-Methylaclacinomycin is a chemically modified derivative of the anthracycline antibiotic aclacinomycin A. This compound is of significant interest in pharmaceutical research and development due to its potential as a lead structure for novel chemotherapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology drug discovery and the study of DNA-interactive compounds.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and evaluation of new anthracycline-based anticancer drugs.
• Oncology Studies: Used in biochemical and pharmacological research to investigate mechanisms of action, such as topoisomerase II inhibition and DNA intercalation.
• Structure-Activity Relationship (SAR) Analysis: Employed to understand how specific chemical modifications, like O-methylation, affect the potency, selectivity, and toxicity profile of anthracycline antibiotics.
• Academic Research: Utilized in university and institutional labs for fundamental studies in medicinal chemistry and molecular biology.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in laboratories analyzing anthracycline compounds.

Basic Information

Product Name	4-o-Methylaclacinomycin
CAS No.	76304-86-4
Molecular Formula	C37H45NO15
Molecular Weight	743.75 g/mol
Synonyms	4-O-Methylaclacinomycin; 4-O-Methylaclacinomycin A; 4-O-Methylaclacinomycin A; 4-O-Methylaclacinomycin A; Aclacinomycin A, 4'-O-methyl-; 4'-O-Methylaclacinomycin A; 4'-O-Methylaclacinomycin; 4'-O-Methylaclacinomycin A
EINECS	Contact for details

Quality Control

Our 4-o-Methylaclacinomycin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable and reproducible results for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the product label/COA. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	Yellow to orange-red powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.