Description

2-Hydroxy Propranolol Hcl is a key pharmaceutical intermediate and metabolite of the β-blocker propranolol. This compound is essential for analytical research, method development, and the synthesis of related active pharmaceutical ingredients. It is primarily utilized by pharmaceutical R&D laboratories, quality control departments, and manufacturers of reference standards and metabolites.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification and identification of propranolol and its metabolites in drug substance and finished product analysis.
• Metabolite Studies: Critical for in-vitro and in-vivo pharmacokinetic and pharmacodynamic research to understand the metabolism, efficacy, and safety profile of propranolol.
• Analytical Method Development: Used as a high-purity standard to develop and validate chromatographic methods (HPLC, LC-MS) for impurity profiling and assay determination.
• Organic Synthesis Intermediate: Employed in the research-scale synthesis of novel propranolol analogs or derivatives for structure-activity relationship (SAR) studies.
• Quality Control & Assurance: Acts as a system suitability and identification standard in Good Manufacturing Practice (GMP) environments to ensure batch consistency and regulatory compliance.
• Clinical Research: Supports bioanalytical testing in clinical trials for accurate measurement of drug and metabolite levels in biological matrices.

Basic Information

Product Name	2-Hydroxy Propranolol Hcl
CAS No.	76275-62-2
Molecular Formula	C₁₆H₂₂ClNO₃
Molecular Weight	311.80 g/mol
Synonyms	1-(Isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol Hydrochloride; 2-Hydroxypropranolol Hydrochloride; 1-(1-Methylethylamino)-3-(1-naphthalenyloxy)-2-propanol Hydrochloride; Propranolol Metabolite II Hydrochloride; 4-[2-Hydroxy-3-(isopropylamino)propoxy]naphthalene-1-carboxylic Acid Hydrochloride (tautomeric form); 2-Hydroxy Propranolol HCl; 2-OH-Propranolol HCl
EINECS	Contact for details

Quality Control

Our 2-Hydroxy Propranolol Hcl is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC and spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.