Description

Norastemizole is a high-purity pharmaceutical intermediate and chemical reference standard. This compound is of significant interest in research and development for its role as a metabolite and a key precursor in the synthesis of advanced therapeutic agents. It is primarily utilized by pharmaceutical manufacturers and R&D laboratories engaged in the development of novel antihistamines and related bioactive molecules. Our supply of Norastemizole CAS NO 75970-99-9 is characterized by stringent quality control to ensure reliability for critical applications.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced antihistamine drugs and their derivatives.
• Active Pharmaceutical Ingredient (API) Development: Serves as a key precursor in the research and scale-up of new therapeutic compounds.
• Metabolite Reference Standard: Used in analytical laboratories for drug metabolism and pharmacokinetic (DMPK) studies, including HPLC and LC-MS analysis.
• Biochemical Research: Employed in pharmacological studies to investigate receptor binding and activity mechanisms.
• Quality Control & Regulatory Testing: Essential for pharmaceutical companies to perform identity, purity, and assay testing against established pharmacopeial standards.

Basic Information

Product Name	Norastemizole
CAS No.	75970-99-9
Molecular Formula	C20H21FN4
Molecular Weight	336.41 g/mol
Synonyms	Desmethylastemizole; Nor-Astemizole; 1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine; 2-Amino-1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazole; Astemizole Impurity; Astemizole Metabolite
EINECS	Contact for details

Quality Control

Our Norastemizole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profiling via advanced techniques like HPLC and GC, to ensure it meets high-purity standards suitable for pharmaceutical R&D. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.