Description

Pafenolol CAS NO 75949-61-0 is a selective β-adrenergic receptor antagonist (β-blocker) used in pharmaceutical research and development. This compound is critical for studying cardiovascular pharmacology and developing new therapeutic agents for conditions such as hypertension and angina. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in drug discovery and preclinical studies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced β-blocker drug candidates.
• Cardiovascular Research: Used as a reference standard or active compound in pharmacological studies targeting β-1 and β-2 adrenergic receptors.
• Preclinical Development: Employed in animal model studies to evaluate efficacy, pharmacokinetics, and safety profiles of new cardiovascular therapies.
• Analytical Standard: Provides a high-purity benchmark for quality control and method development in analytical laboratories (HPLC, LC-MS).
• Biochemical Assays: Utilized in in vitro assays to study receptor binding affinity and functional activity.

Basic Information

Product Name	Pafenolol
CAS No.	75949-61-0
Molecular Formula	C16H24N2O3
Molecular Weight	292.38 g/mol
Synonyms	Pafenolol; (±)-Pafenolol; 1-(4-Acetamidophenoxy)-3-(isopropylamino)-2-propanol; 4'-[2-Hydroxy-3-(isopropylamino)propoxy]acetanilide; BRN 2934813; CHEMBL2103875; Pafenolol [INN]; UNII-5J27391Q3P
EINECS	Contact for details

Quality Control

Our Pafenolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data (HPLC) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.