Description

3β-[[(3,3,4,4,5,5,5-Heptafluoropentyl)Dimethylsilyl]Oxy]Cholest-5-Ene is a high-value, organofluorine-modified steroidal intermediate, distinguished by its unique heptafluoropentyl-dimethylsilyl (HFPS) protecting group. This compound is critical for advanced synthetic chemistry, offering enhanced lipophilicity and metabolic stability in target molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel steroid-based therapeutics, diagnostic agents, and high-performance liquid crystal materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated steroid analogs with potential therapeutic applications.
• Advanced Material Science: Used in the research and development of fluorinated liquid crystals for display technologies.
• Biochemical Research: Serves as a probe or labeled compound in metabolic studies and receptor binding assays due to its fluorine tags.
• Organic Synthesis: Valuable intermediate for introducing steroidal frameworks with specific, protected functionalities in complex multi-step syntheses.
• Protecting Group Chemistry: The HFPS group provides a robust, selectively cleavable protecting group for hydroxyl functions under mild conditions.

Basic Information

Item	Details
Product Name	3β-[[(3,3,4,4,5,5,5-Heptafluoropentyl)Dimethylsilyl]Oxy]Cholest-5-Ene
CAS No.	75943-60-1
Molecular Formula	C₃₆H₅₉F₇OSi
Molecular Weight	668.93 g/mol
Synonyms	Cholest-5-en-3β-ol, 3-[(3,3,4,4,5,5,5-heptafluoropentyl)dimethylsilyl]oxy]-; 3β-HFPS-Cholest-5-ene; 3β-[(Heptafluoropentyldimethylsilyl)oxy]cholest-5-ene; (3β)-Cholest-5-en-3-yl (3,3,4,4,5,5,5-heptafluoropentyl)dimethylsilyl ether; HFPS-Cholesterol derivative; Heptafluoropentyldimethylsilyl cholesterol ether
EINECS	Contact for details

Quality Control

Our production of 3β-[[(3,3,4,4,5,5,5-Heptafluoropentyl)Dimethylsilyl]Oxy]Cholest-5-Ene adheres to stringent quality management protocols. Each batch is characterized and purified to meet exacting standards for research and development use. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opened for use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.