Description

Beclomethasone Hemisuccinate is a key pharmaceutical intermediate and a derivative of the potent glucocorticoid beclomethasone. This compound is essential for the synthesis of advanced corticosteroid formulations, offering a critical building block for enhanced drug delivery and stability. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development of inhalation therapies, topical creams, and other anti-inflammatory medications.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A crucial precursor in the synthesis of beclomethasone dipropionate and other corticosteroid APIs.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies to develop new anti-inflammatory and immunosuppressive drugs.
• Formulation of Inhalation Products: Serves as a starting material for manufacturing metered-dose inhalers (MDIs) and dry powder inhalers (DPIs) for asthma and COPD treatment.
• Topical Corticosteroid Production: Employed in creating creams, ointments, and lotions for treating dermatological conditions like eczema and psoriasis.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for HPLC and other chromatographic methods.
• Process Chemistry: Utilized in scaling up and optimizing synthetic routes for corticosteroid manufacturing.

Basic Information

Product Name	Beclomethasone Hemisuccinate
CAS No.	75899-57-9
Molecular Formula	C28H35ClO8
Molecular Weight	535.03 g/mol
Synonyms	9α-Chloro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-hemisuccinate; Beclometasone Hemisuccinate; Beclomethasone 21-Hemisuccinate; NSC 394000
EINECS	Contact for details

Quality Control

Our Beclomethasone Hemisuccinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) are provided, detailing results for identity, purity, and related substances. We can supply material compliant with in-house specifications aligned with ICH Q3A/B guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.