Description

Betamethasone 21-Propionate is a synthetic corticosteroid ester, specifically the 21-propionate derivative of betamethasone. This compound is a key pharmaceutical intermediate of significant importance in the development of potent topical anti-inflammatory and anti-pruritic medications. It is primarily utilized by pharmaceutical manufacturers and research institutions in the synthesis of advanced dermatological corticosteroids. The high purity and consistent quality of this intermediate are critical for ensuring the efficacy and safety of the final drug products.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of finished corticosteroid APIs for topical formulations.
• Topical Corticosteroid Production: A key precursor in manufacturing creams, ointments, and lotions for treating skin conditions like eczema, psoriasis, and dermatitis.
• Veterinary Medicine: Used in the development of anti-inflammatory treatments for animals.
• Research & Development: Serves as a reference standard and building block in medicinal chemistry research for novel steroid-based therapies.
• Dermatological Product Development: Employed in formulating combination products that include corticosteroids with other active ingredients.

Basic Information

Product Name	Betamethasone 21-Propionate
CAS No.	75883-07-7
Molecular Formula	C26H35FO6
Molecular Weight	462.56 g/mol
Synonyms	Betamethasone 17-propionate; 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-propionate; 21-(1-Oxopropoxy)-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione; Betamethasone propionate (ester); NSC-39471
EINECS	Contact for details

Quality Control

Our Betamethasone 21-Propionate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for assay and related substances, to ensure it meets high-purity standards suitable for pharmaceutical synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP guidelines for active pharmaceutical ingredients (APIs) and intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.