Description

21-Chloro Hydrocortisone is a key halogenated derivative of the endogenous glucocorticoid hydrocortisone. This modification significantly alters its biological activity and metabolic profile, making it a valuable intermediate for pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors. The compound is essential for synthesizing novel steroid-based therapeutics and probing structure-activity relationships.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel corticosteroid analogs with potential enhanced potency or modified metabolic stability.
• Research Chemical: Used in biochemical and pharmacological research to study glucocorticoid receptor interactions and signaling pathways.
• Metabolite Standard: Serves as a reference standard in analytical laboratories for the identification and quantification of steroid metabolites in biological samples.
• Process Development: Employed in the scale-up and optimization of synthetic routes for advanced steroid active pharmaceutical ingredients (APIs).
• Medicinal Chemistry: A versatile scaffold for creating targeted libraries of compounds to explore new therapeutic areas for inflammatory and autoimmune diseases.

Basic Information

Product Name	21-Chloro Hydrocortisone
CAS No.	75868-48-3
Molecular Formula	C21H29ClO5
Molecular Weight	396.91 g/mol
Synonyms	21-Chlorocortisol; 21-Chloro-11β,17α,21-trihydroxypregn-4-ene-3,20-dione; 21-Chloro-11β,17,21-trihydroxypregn-4-ene-3,20-dione; 11β,17α,21-Trihydroxy-21-chloropregn-4-ene-3,20-dione; Hydrocortisone 21-chloride; Cortisol 21-chloride
EINECS	Contact for details

Quality Control

Our 21-Chloro Hydrocortisone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and specific tests for residual solvents and related substances. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under conditions of low humidity to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.