Description

Aclarubicin Hydrochloride is a semi-synthetic anthracycline antibiotic and potent antineoplastic agent. It is valued for its mechanism of action, which involves intercalation into DNA and inhibition of topoisomerase II, leading to cytotoxic effects. This compound is primarily utilized in pharmaceutical research and development for the investigation of novel cancer therapeutics, particularly in the study of leukemia and solid tumors.

Application

• Oncology Research: A key reference standard and active pharmaceutical ingredient (API) in preclinical and clinical research for cancer treatment.
• Biochemical Studies: Used to study mechanisms of DNA intercalation, topoisomerase II inhibition, and apoptosis induction.
• Pharmaceutical Development: Serves as a critical intermediate or model compound in the synthesis and development of new anthracycline derivatives.
• Cell Culture & In Vitro Assays: Employed in cytotoxicity screenings and efficacy testing against various cancer cell lines.
• Academic Research: Utilized in university and institutional laboratories for fundamental cancer biology and pharmacology studies.

Basic Information

Product Name	Aclarubicin Hydrochloride
CAS No.	75443-99-1
Molecular Formula	C42H53NO15 • HCl
Molecular Weight	848.33 g/mol (for free base C42H53NO15)
Synonyms	Aclacinomycin A Hydrochloride; Aclarubicin HCl; ACM-A; Aclacinomycin Hydrochloride; 2-Ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-1-naphthacenecarboxylic acid methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our Aclarubicin Hydrochloride is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-grade standards suitable for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment away from direct light exposure to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.