Description

Adriamycin Octanoylhydrazone is a chemically modified derivative of the anthracycline antibiotic doxorubicin, designed to enhance its therapeutic profile. This compound is significant for its potential to reduce cardiotoxicity while retaining or improving antitumor efficacy, making it a valuable intermediate in advanced pharmaceutical research and development. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing novel oncology therapeutics and studying drug delivery mechanisms.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of novel, less cardiotoxic anthracycline-based chemotherapeutic agents.
• Oncology Research: Used in biochemical and pharmacological studies to investigate mechanisms of action, tumor cell targeting, and resistance pathways.
• Drug Delivery System Development: Serves as a model compound for developing prodrugs and targeted delivery systems, such as antibody-drug conjugates (ADCs) or nanoparticle formulations.
• Bioconjugation Studies: Utilized in research exploring the conjugation of chemotherapeutic agents to carriers like polymers, peptides, or antibodies to improve specificity.
• Comparative Efficacy Studies: Employed in preclinical research to compare the potency and side-effect profiles against parent compounds like doxorubicin.
• Academic and Institutional Research: Fundamental tool for universities and research institutes studying cancer biology and medicinal chemistry.

Basic Information

Product Name	Adriamycin Octanoylhydrazone
CAS No.	75301-02-9
Molecular Formula	C₃₅H₄₃N₃O₁₁
Molecular Weight	681.73 g/mol
Synonyms	Doxorubicin Octanoylhydrazone; Doxorubicin 14-Octanoylhydrazone; AD 198; AD-198; Adriamycin-14-octanoyl hydrazone; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione 14-octanoylhydrazone
EINECS	Contact for details

Quality Control

Our Adriamycin Octanoylhydrazone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.