Description

3-Chloro-4-Fluorophenylacetonitrile is a versatile and high-value aromatic nitrile building block, essential for advanced organic synthesis. Its core value lies in providing a reactive cyano group adjacent to a substituted phenyl ring, enabling efficient construction of complex heterocycles and active pharmaceutical ingredients (APIs). This compound is critically needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the chloro-fluoro-phenyl moiety contributes to biological efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and advanced polymers due to its aromatic and electron-withdrawing characteristics.
• Custom Synthesis and Contract Manufacturing: A fundamental building block for custom chemical synthesis services catering to biotechnology and fine chemical sectors.

Basic Information

Product Name	3-Chloro-4-Fluorophenylacetonitrile
CAS No.	75279-56-0
Molecular Formula	C8H5ClFN
Molecular Weight	169.58 g/mol
Synonyms	(3-Chloro-4-fluorophenyl)acetonitrile; 2-(3-Chloro-4-fluorophenyl)acetonitrile; 3-Chloro-4-fluorobenzyl cyanide; 3-Chloro-4-fluorobenzeneacetonitrile; 3-Chloro-4-fluoro-α-tolunitrile; 3-Chloro-4-fluorophenylethanenitrile; 3-Chloro-4-fluorophenyl cyanomethyl; 3-Chloro-4-fluoro-benzylnitrile
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Fluorophenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We support cGMP and ISO 9001 standards for pharmaceutical and industrial grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, open flames, and strong oxidizing agents. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.