Description

4-Chloro-2-Fluorophenylacetonitrile is a versatile and high-purity fluorinated aromatic nitrile building block. This compound is critical for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its unique halogenated structure enables precise chemical modifications. It is primarily sought after by research chemists and process development scientists for creating active pharmaceutical ingredients (APIs), advanced agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine and chlorine substituents for enhanced biological activity and stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Sonogashira) and cyano-group transformations for constructing complex aromatic systems.
• Chemical Research & Development: Essential for academic and industrial R&D exploring new fluorinated compounds and their properties.
• Material Science: Potential use in the synthesis of polymers and advanced organic materials with specific electronic or optical properties.

Basic Information

Product Name	4-Chloro-2-Fluorophenylacetonitrile
CAS No.	75279-53-7
Molecular Formula	C8H5ClFN
Molecular Weight	169.58 g/mol
Synonyms	(4-Chloro-2-fluorophenyl)acetonitrile; 2-Fluoro-4-chlorophenylacetonitrile; 4-Chloro-2-fluorobenzyl cyanide; (2-Fluoro-4-chlorophenyl)acetonitrile; p-Chloro-o-fluorophenylacetonitrile; 75279-53-7; α-Cyano-4-chloro-2-fluorotoluene; 4-Chloro-2-fluoro-α-tolunitrile
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluorophenylacetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly closed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.