Description

Ethanone, 1-[1-(1,1-Dimethylethyl)-1H-Pyrrol-3-Yl]-2,2,2-Trifluoro- (9Ci) is a high-purity, specialized trifluoromethyl ketone derivative featuring a tert-butyl pyrrole moiety, offering a unique combination of steric bulk and electronic properties. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic organic chemistry, enabling the development of novel molecular architectures. It is primarily sought by R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecules with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, where the trifluoromethyl group contributes to biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and other functional materials due to its electron-withdrawing characteristics.
• Fluorine Chemistry Studies: A valuable reagent for investigating structure-activity relationships (SAR) and introducing fluorine atoms into complex molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Item	Details
Product Name	Ethanone, 1-[1-(1,1-Dimethylethyl)-1H-Pyrrol-3-Yl]-2,2,2-Trifluoro- (9Ci)
CAS No.	74889-36-4
Molecular Formula	C10H12F3NO
Molecular Weight	219.20 g/mol
Synonyms	1-(1-tert-Butyl-1H-pyrrol-3-yl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(1-tert-butylpyrrol-3-yl)ethanone; 1-[1-(tert-Butyl)-1H-pyrrol-3-yl]-2,2,2-trifluoroethanone; 3-Trifluoroacetyl-1-tert-butylpyrrole; tert-Butyl 3-trifluoroacetylpyrrole; N-tert-Butyl-3-trifluoroacetylpyrrole; 74889-36-4 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Every batch of our Ethanone, 1-[1-(1,1-Dimethylethyl)-1H-Pyrrol-3-Yl]-2,2,2-Trifluoro- (9Ci) is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot. Our quality commitment aligns with the standards expected in GMP-like environments for non-pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.