Description

Cortisol 21-Benzoate is a synthetic corticosteroid derivative, specifically the 21-hydroxy ester of cortisol. This compound is a key pharmaceutical intermediate of significant interest for the development of advanced steroid-based therapeutics. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the synthesis of novel anti-inflammatory and immunosuppressive agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel corticosteroid drugs and prodrugs.
• Biochemical Research: Used as a reference standard and starting material in steroid metabolism and receptor-binding studies.
• Prodrug Development: Serves as a precursor for creating ester prodrugs of cortisol to modify solubility, bioavailability, and pharmacokinetic profiles.
• Anti-inflammatory Agent Synthesis: Employed in R&D for creating new topical or systemic corticosteroid formulations with targeted activity.
• Veterinary Medicine: Potential use in developing specialized corticosteroid treatments for animal health applications.

Basic Information

Product Name	Cortisol 21-Benzoate
CAS No.	74669-84-4
Molecular Formula	C28H36O6
Molecular Weight	468.59 g/mol
Synonyms	Hydrocortisone 21-Benzoate; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 21-benzoate; Cortisol 21-(Benzoate); 21-Benzoyloxycortisol; (11β)-11,17,21-Trihydroxypregn-4-ene-3,20-dione 21-benzoate
EINECS	Contact for details

Quality Control

Our Cortisol 21-Benzoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR), and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.