Description

1A-Demethylmitomycin G is a specialized derivative of the potent mitomycin family of antitumor antibiotics. This compound is of significant interest in advanced pharmaceutical research and development, particularly for its potential role in studying structure-activity relationships and developing novel therapeutic agents. It serves as a critical intermediate and reference standard for researchers in oncology and medicinal chemistry. The target markets include global pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on anticancer drug discovery.

Application

• Pharmaceutical Research Intermediate: Serves as a key synthetic precursor or building block in the development of novel mitomycin-based anticancer agents.
• Reference Standard for Analytical Development: Used for method development, validation, and quality control (HPLC, LC-MS) in pharmaceutical analysis.
• Biochemical Research: Employed in in vitro studies to investigate mechanisms of action, DNA alkylation, and cytotoxicity profiles.
• Medicinal Chemistry Studies: Utilized to explore structure-activity relationships (SAR) within the mitomycin class to optimize potency and reduce toxicity.
• Academic Research: A valuable tool for university laboratories conducting research in organic synthesis, chemical biology, and experimental oncology.

Basic Information

Product Name	1A-Demethylmitomycin G
CAS No.	74422-23-4
Molecular Formula	C14H17N3O5
Molecular Weight	307.30 g/mol
Synonyms	1a-Demethylmitomycin G; 7-Amino-9a-methoxy-1a,2,8,8a-tetrahydro-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione; Mitomycin derivative; 1-Desmethylmitomycin G; 1-Demethylmitomycin G; Antibiotic derivative FR 900482; FR-900482 related compound
EINECS	Contact for details

Quality Control

Our 1A-Demethylmitomycin G is produced under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for research applications. Each batch undergoes rigorous analytical testing, including HPLC for purity determination and spectroscopic methods (NMR, MS) for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.