Description

2-Amino-5-Chloro-3-Trifluoromethyl-Benzonitrile is a high-value, multi-functional aromatic nitrile building block. This compound matters for its unique trifluoromethyl and amino-chloro substitution pattern, which imparts significant electronic and steric properties crucial for advanced synthesis. It is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for developing novel active ingredients, including potential herbicides, fungicides, and pharmaceutical intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Serves as a critical precursor in the manufacture of advanced herbicides and fungicides, leveraging the bioactivity of the trifluoromethyl group.
• Material Science Research: Used in the synthesis of specialized dyes, pigments, and functional organic materials due to its electron-withdrawing substituents.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalytic processes.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring complex, fluorinated aromatic structures.

Basic Information

Product Name	2-Amino-5-Chloro-3-Trifluoromethyl-Benzonitrile
CAS No.	74396-76-2
Molecular Formula	C8H4ClF3N2
Molecular Weight	220.58 g/mol
Synonyms	2-Amino-5-chloro-α,α,α-trifluoro-m-toluonitrile; 5-Chloro-2-amino-α,α,α-trifluoro-m-toluonitrile; Benzonitrile, 2-amino-5-chloro-3-(trifluoromethyl)-; 2-Amino-5-chloro-3-trifluoromethylbenzonitrile; 3-Trifluoromethyl-2-amino-5-chlorobenzonitrile; 5-Chloro-2-amino-3-trifluoromethylbenzonitrile; 2-Amino-5-chloro-α,α,α-trifluoro-m-tolunitrile
EINECS	Contact for details

Quality Control

Our 2-Amino-5-Chloro-3-Trifluoromethyl-Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.