Description

1-Hydroxy-13-Dihydrodaunomycin is a key intermediate and derivative of the anthracycline class of compounds, known for its significance in pharmaceutical research and development. This compound is valued for its role in the synthesis and study of more complex chemotherapeutic agents, providing a crucial building block for anticancer drug discovery. It is primarily sought by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing novel oncology treatments and studying anthracycline metabolism and mechanisms of action.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel anthracycline-based chemotherapeutic agents and their derivatives.
• Biochemical Research: Used in academic and industrial laboratories to study the structure-activity relationships (SAR) of daunomycin analogs and their interaction with DNA.
• Metabolite Standard: Acts as a reference standard in analytical chemistry for the identification and quantification of daunorubicin metabolites in pharmacokinetic and pharmacodynamic studies.
• Anticancer Drug Development: Employed in early-stage drug discovery programs focused on modifying anthracycline scaffolds to reduce cardiotoxicity or overcome drug resistance.
• Mechanistic Studies: Utilized to investigate the biochemical pathways and enzymatic reductions involved in the metabolism of daunorubicin and related compounds.

Basic Information

Product Name	1-Hydroxy-13-Dihydrodaunomycin
CAS No.	74273-36-2
Molecular Formula	C27H29NO10
Molecular Weight	527.52 g/mol
Synonyms	13-Dihydrodaunorubicin; 13-Dihydrodaunomycin; 1-Hydroxy-13-dihydrodaunorubicin; Daunorubicinol; 7-Deoxy-13-dihydrodaunorubicinone; 1-Hydroxy-7,8,9,10-tetrahydro-6,11-dihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione; (8S,10S)-8-Acetyl-10-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione
EINECS	Contact for details

Quality Control

Our 1-Hydroxy-13-Dihydrodaunomycin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing purity, identity, and relevant physicochemical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.