Description

Aldosterone 18-Oxime 21-Acetate is a key synthetic derivative of the mineralocorticoid hormone aldosterone, specifically modified at the 18 and 21 positions. This compound is of significant value in pharmaceutical research and development, serving as a crucial intermediate or reference standard. It is primarily needed by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in steroid chemistry, endocrinology research, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthetic pathway for novel steroid-based pharmaceuticals and potential drug candidates.
• Biochemical Research: Used as a tool compound in studies investigating mineralocorticoid receptor (MR) function, signaling pathways, and hormone action.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in HPLC, LC-MS, or other chromatographic assays.
• Metabolite Studies: Employed in research to understand the metabolism and biotransformation pathways of aldosterone and related steroids.
• Chemical Synthesis: Utilized by medicinal chemists for the design and synthesis of steroid analogs with modified biological activity.

Basic Information

Product Name	Aldosterone 18-Oxime 21-Acetate
CAS No.	74220-49-8
Molecular Formula	C23H32O6
Molecular Weight	404.50 g/mol
Synonyms	18,21-Dihydroxy-11β,21-epoxypregn-4-ene-3,20-dione 18-oxime 21-acetate; 11β,21-Epoxy-18,21-dihydroxypregn-4-ene-3,20-dione 18-oxime 21-acetate; Aldosterone 18-(O-methyloxime) 21-acetate; 18-Oxoaldosterone 21-acetate oxime
EINECS	Contact for details

Quality Control

Our Aldosterone 18-Oxime 21-Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and development applications. Certificates of Analysis (COA) detailing specific batch results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.