Description

7-Amino-10-Decarbamoyloxy-9-Dehydro-7-Demethoxymitomycin B is a structurally complex and highly potent derivative of the mitomycin family of antitumor antibiotics. This compound matters as a critical advanced intermediate in pharmaceutical research and development, particularly for the synthesis of novel chemotherapeutic agents and targeted cancer therapies. It is primarily needed by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in oncology drug discovery and the production of high-value active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of next-generation mitomycin-based anticancer drugs and prodrugs.
• Oncology Research: Used as a reference standard and biochemical tool in cancer research to study DNA alkylation, cross-linking mechanisms, and tumor cell cytotoxicity.
• API Development: Employed in the research, process development, and scale-up manufacturing of novel Active Pharmaceutical Ingredients (APIs) targeting solid tumors.
• Bioconjugation Studies: Utilized in the development of antibody-drug conjugates (ADCs) and other targeted delivery systems due to its potent cytotoxic payload potential.
• Mechanistic Studies: Applied in academic and industrial laboratories to investigate the structure-activity relationships (SAR) within the mitomycin class of compounds.

Basic Information

Item	Details
Product Name	7-Amino-10-Decarbamoyloxy-9-Dehydro-7-Demethoxymitomycin B
CAS No.	74148-47-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	7-Amino-10-decarbamoyloxy-9-dehydro-7-demethoxymitomycin B; 7-AD-9-D-7-DMMB; Mitomycin B derivative; 7-Amino-10-(aminocarbonyloxy)-9-dehydro-7-demethoxymitomycin B; Antitumor antibiotic intermediate; 7-AD-7-DMMB; 7-Amino-10-O-carbamoyl-9-dehydro-7-demethoxymitomycin B
EINECS	Contact for details

Quality Control

Our 7-Amino-10-Decarbamoyloxy-9-Dehydro-7-Demethoxymitomycin B is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Single Unknown Impurity	≤ 1.0%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.