Description

10-Decarbamoyloxy-9-Dehydromitomycin B is a specialized derivative of the potent mitomycin family of antitumor antibiotics. This compound is of significant interest in pharmaceutical research and development, particularly for its role as a key intermediate or reference standard in the synthesis and study of novel chemotherapeutic agents. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers focused on oncology drug discovery and advanced chemical synthesis.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel mitomycin analogs and related anticancer compounds.
• Biochemical Research: Used as a reference standard in studies investigating the structure-activity relationships (SAR) of mitomycins and their mechanisms of action.
• Antitumor Agent Development: Acts as a precursor or model compound in the research and development of new chemotherapeutic drugs targeting DNA cross-linking.
• Analytical Standard: Employed in high-performance liquid chromatography (HPLC) and mass spectrometry (MS) for method development, calibration, and quality control of related substances.

Basic Information

Product Name	10-Decarbamoyloxy-9-Dehydromitomycin B
CAS No.	74148-44-0
Molecular Formula	C14H17N3O5
Molecular Weight	307.30 g/mol
Synonyms	9-Dehydro-10-decarbamoyloxymitomycin B; 10-Decarbamoyloxy-9-dehydromitomycin B; Mitomycin B derivative; 7-Amino-9α-methoxymitosane-6,10-dicarbamic acid 10-methyl ester; (1aS,8S,8aR,8bS)-6-Amino-8a-methoxy-5-methyl-4,7-dioxo-1a,2,3,8,8a,8b-hexahydro-1H-azirino[2',3':3,4]pyrrolo[1,2-a]indole-8-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 10-Decarbamoyloxy-9-Dehydromitomycin B is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Total Impurities	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.