Description

(±)-n-[3-Acetyl-4-[2-Hydroxy-3-[(1-Methylethyl)Amino]Propoxy]Phenyl]Acetamide Monohydrochloride is a high-purity pharmaceutical intermediate and research chemical of significant commercial interest. This compound is valued for its role as a key synthetic precursor in the development of active pharmaceutical ingredients (APIs), particularly in the cardiovascular and adrenergic receptor modulator therapeutic classes. It is primarily sought by pharmaceutical manufacturers, contract research organizations (CROs), and advanced chemical synthesis laboratories for process development and scale-up activities.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of β-adrenergic blocking agents (β-blockers).
• Active Pharmaceutical Ingredient (API) Development: Used in research and process chemistry for developing new cardiovascular drugs.
• Biochemical Research: Serves as a reference standard and tool compound in pharmacological studies targeting adrenergic receptors.
• Process Chemistry & Scale-up: Employed in optimizing synthetic routes and scaling production from laboratory to pilot and commercial scale.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of finished dosage forms.

Basic Information

Product Name	(±)-n-[3-Acetyl-4-[2-Hydroxy-3-[(1-Methylethyl)Amino]Propoxy]Phenyl]Acetamide Monohydrochloride
CAS No.	73899-76-0
Molecular Formula	C16H25ClN2O4
Molecular Weight	344.83 g/mol
Synonyms	N-[3-Acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]acetamide hydrochloride; Acebutolol Impurity; Acebutolol Related Compound; 1-(4-Acetamido-3-acetylphenoxy)-3-(isopropylamino)-2-propanol hydrochloride; (±)-Acebutolol Hydrochloride; DL-Acebutolol Hydrochloride; 3'-Acetyl-4'-(2-hydroxy-3-isopropylaminopropoxy)butyranilide Hydrochloride
EINECS	Contact for details

Quality Control

Our production of (±)-n-[3-Acetyl-4-[2-Hydroxy-3-[(1-Methylethyl)Amino]Propoxy]Phenyl]Acetamide Monohydrochloride adheres to stringent quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting full compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to exclude moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.