Description

Promethazine is a phenothiazine derivative with significant pharmacological activity, widely recognized for its antihistaminic and sedative properties. This versatile active pharmaceutical ingredient (API) is crucial for the formulation of reliable and effective therapeutic agents. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development of medications targeting allergic conditions, motion sickness, and as a pre-anesthetic sedative.

Application

• Pharmaceutical Formulations: Primary active ingredient in antihistamine and antiemetic medications.
• Allergy Management: Used in products for the symptomatic relief of allergic rhinitis, conjunctivitis, and skin reactions.
• Motion Sickness Prevention: Key component in prophylactic treatments for nausea and vomiting associated with travel.
• Sedative Applications: Employed in pre-operative and post-operative care for its calming and sleep-inducing effects.
• Research & Development: Serves as a critical reference standard and intermediate in pharmacological and biochemical research.
• Veterinary Medicine: Applied in veterinary pharmaceuticals for similar antihistaminic and sedative purposes.

Basic Information

Product Name	Promethazine
CAS No.	73745-50-3
Molecular Formula	C17H20N2S
Molecular Weight	284.42 g/mol
Synonyms	Promethazine; 10-[2-(Dimethylamino)propyl]phenothiazine; N,N,α-Trimethyl-10H-phenothiazine-10-ethanamine; Phenergan (trade name); Atosil; Prothazin; Lergigan; Dimap; Pipolphen; Histantil; Fargan; Romergan; Ganphen; Pentazine; Promazinamide; Protazine
EINECS	Contact for details

Quality Control

Our Promethazine is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical applications. Quality is verified through comprehensive analytical testing, including identification, assay, and impurity profiling via techniques such as HPLC, IR spectroscopy, and titration. We can supply material compliant with various pharmacopoeial standards (e.g., USP, EP) upon request. A Certificate of Analysis (COA) is provided with each batch to guarantee purity, identity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.