Description

Daunorubicin Semiquinone Radicals are a critical intermediate species in the metabolic activation pathway of the anthracycline antibiotic daunorubicin. This compound is of significant importance for researchers investigating the mechanisms of action, cardiotoxicity, and potential redox-modulating strategies related to this class of chemotherapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic institutions, and analytical service providers focused on oncology drug metabolism and oxidative stress studies.

Application

• Mechanistic Studies in Oncology Research: Investigation of the bioreductive activation pathway of daunorubicin and related anthracyclines.
• Cardiotoxicity Research: Used as a reference standard or model compound to study the role of semiquinone radicals in mediating the dose-limiting cardiac side effects of anthracycline therapy.
• Redox Biology and Free Radical Research: Serves as a tool compound for studying electron transfer reactions, free radical generation, and oxidative stress in biological systems.
• Analytical Reference Standard: Employed in the development and validation of analytical methods (e.g., HPLC, LC-MS, EPR) for detecting and quantifying reactive drug metabolites.
• Biochemical Assay Development: Used in designing in vitro assays to screen for compounds that modulate semiquinone formation or stability.
• Pharmaceutical Impurity Profiling: Potential use as a reference for identifying and characterizing related substances or degradation products in daunorubicin drug substance and product analysis.

Basic Information

Item	Detail
Product Name	Daunorubicin Semiquinone Radicals
CAS No.	73610-99-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Daunorubicin Semiquinone; Daunorubicin Free Radical; Daunomycin Semiquinone; (8S,10S)-8-Acetyl-10-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,8,11-trihydroxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione Semiquinone Radical; Daunorubicin Intermediate Radical; NSC-82151 Semiquinone; DRB Semiquinone
EINECS	Contact for details

Quality Control

Our Daunorubicin Semiquinone Radicals are produced and handled under controlled conditions to ensure stability and integrity for research purposes. While specific pharmacopeial monographs may not apply to this research chemical, each batch is characterized to confirm identity and purity profile. Certificates of Analysis (COA) detailing batch-specific analytical data are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at recommended cold storage temperatures (e.g., -20°C or below) to minimize oxidation and degradation. Allow the container to reach room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Contact for details
Identification (IR / NMR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95% (Area %)
Related Substances (HPLC)	Contact for details
Solvent Content (Residual Solvents)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.