Description

Threo-Ici 118551 Hydrochloride is a high-purity chemical compound, specifically the hydrochloride salt form of a stereoisomer, valued for its defined molecular structure and consistent performance in advanced research and development. This compound is critical for pharmaceutical and biochemical applications where precise stereochemistry and salt form can significantly influence biological activity and physicochemical properties. It serves as a key intermediate or reference standard for researchers in medicinal chemistry, process development, and analytical method validation.

Application

• Pharmaceutical Research & Development: Used as a critical intermediate or building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly where the threo configuration is required for biological activity.
• Medicinal Chemistry Studies: Serves as a reference standard or a precursor for structure-activity relationship (SAR) studies to optimize drug candidate profiles.
• Process Chemistry & Scale-up: Employed in route development and optimization for the commercial manufacturing of complex drug molecules.
• Analytical Method Development: Acts as a high-purity standard for HPLC, LC-MS, or NMR to validate analytical methods for quality control and impurity profiling.
• Biochemical Research: May be utilized in biochemical assays to study enzyme interactions, receptor binding, or other biological mechanisms.
• Academic Research: Provides a well-defined chemical entity for university and institutional research projects in organic synthesis and pharmacology.

Basic Information

Product Name	Threo-Ici 118551 Hydrochloride
CAS No.	72795-04-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ICI 118551 Hydrochloride, Threo-Form; Erythro-1-(7-Methylindan-4-yloxy)-3-isopropylaminobutan-2-ol Hydrochloride (Threo isomer); ICI-118,551 HCl; (2S,3R)-1-(7-Methylindan-4-yloxy)-3-[(propan-2-yl)amino]butan-2-ol Hydrochloride; β-Adrenergic Blocker ICI 118551 Hydrochloride (Threo); ICI-118551 (Threo) HCl; Threo Isomer of ICI 118551 HCl
EINECS	Contact for details

Quality Control

Our Threo-Ici 118551 Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification, assay, and impurity profiling, to meet the stringent requirements of research and development applications. A Certificate of Analysis (COA) detailing specific results for purity (typically by HPLC), chiral purity, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (Threo isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.