Description

Actinomycin D1 CAS NO 72766-92-8 is a potent antibiotic and antitumor agent belonging to the actinomycin family. Its primary value lies in its ability to intercalate into DNA, inhibiting transcription, which makes it a critical tool in biochemical research and a model compound for studying cytotoxic mechanisms. This product is essential for pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on oncology research, molecular biology, and the development of novel chemotherapeutic agents.

Application

• Oncology Research: Used as a reference standard and active compound in studies of apoptosis, DNA damage, and cancer cell cytotoxicity.
• Biochemical Studies: Employed to inhibit RNA synthesis in molecular biology experiments to investigate transcriptional regulation and gene expression.
• Pharmaceutical Development: Serves as a key intermediate or reference material in the research and development of new anticancer drugs and targeted therapies.
• Microbiological Research: Acts as a potent antibiotic in studies of bacterial genetics and mechanisms of antibiotic action.
• Cell Biology: Utilized in cell culture studies to induce cell cycle arrest and study cellular stress responses.

Basic Information

Product Name	Actinomycin D1
CAS No.	72766-92-8
Molecular Formula	C62H86N12O16
Molecular Weight	1255.42 g/mol
Synonyms	Actinomycin D1; Actinomycin IV; Actinomycin D (minor component); 7-Amino-actinomycin D1; Dactinomycin derivative; NSC 3053 (related); Cosmegen congener; Actinomycin C1 (historical reference)
EINECS	Contact for details

Quality Control

Our Actinomycin D1 is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity and assay, identity confirmation by spectroscopic methods, and stringent control of related substances and residual solvents. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to ensure full traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Red crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.