Description

Pirarubicin CAS NO 72496-41-4 is a semi-synthetic anthracycline antibiotic derivative, valued for its potent antineoplastic activity. It is a critical active pharmaceutical ingredient (API) used in the formulation of injectable chemotherapeutic agents. This compound is primarily required by pharmaceutical manufacturers and research institutions engaged in oncology drug development and production.

Application

• Oncological Pharmaceutical Formulations: Primary use as the active ingredient in injectable chemotherapy drugs for the treatment of various cancers.
• Bladder Cancer Therapy: Specifically utilized in intravesical instillation treatments for superficial bladder cancer.
• Clinical Research & Development: Serves as a reference standard and key intermediate in the R&D of novel anthracycline-based cancer therapies.
• Mechanistic Studies: Used in biochemical and pharmacological research to study DNA intercalation and topoisomerase II inhibition.
• Generic Drug Manufacturing: Essential for companies producing generic versions of established pirarubicin-based chemotherapeutics.

Basic Information

Product Name	Pirarubicin
CAS No.	72496-41-4
Molecular Formula	C32H37NO12
Molecular Weight	627.64 g/mol
Synonyms	THP-Adriamycin; 4'-O-Tetrahydropyranyladriamycin; Pirarubicin Hydrochloride; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; 4'-O-Tetrahydropyranyl Doxorubicin; THP-DOX; RP-56976
EINECS	Contact for details

Quality Control

Our Pirarubicin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, identification by IR and NMR spectroscopy, and stringent control of related substances and residual solvents. Certificates of Analysis (COA) confirming compliance with in-house pharmaceutical-grade specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled temperature of 2-8°C. The product is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	Orange-red to red crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 3.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.