Description

11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-Acetate 17-Valerate is a high-purity synthetic corticosteroid intermediate of significant commercial and pharmaceutical importance. This compound serves as a critical building block in the synthesis of potent topical and systemic anti-inflammatory steroid APIs. It is essential for manufacturers in the pharmaceutical industry requiring reliable, high-quality raw materials for the production of advanced corticosteroid medications.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potent topical corticosteroids such as Betamethasone Valerate and related derivatives.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the controlled production of steroid-based APIs for anti-inflammatory and immunosuppressive therapies.
• Research & Development: Serves as a standard or starting material in pharmaceutical R&D for developing new steroid analogs and exploring structure-activity relationships.
• Dermatological Preparations: Found in the supply chain for creams, ointments, and lotions designed to treat eczema, psoriasis, and other inflammatory skin conditions.
• Veterinary Pharmaceuticals: Employed in the formulation of anti-inflammatory treatments for animals.

Basic Information

Product Name	11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-Acetate 17-Valerate
CAS No.	72064-79-0
Molecular Formula	C₂₈H₃₈O₇
Molecular Weight	486.60 g/mol
Synonyms	Betamethasone 17-Valerate 21-Acetate; 9α-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-acetate 17-valerate; Betamethasone Valerate Acetate; NSC 39471; 11β,17,21-Trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-acetate 17-valerate (related); Betamethasone 21-acetate 17-valerate
EINECS	Contact for details

Quality Control

Our 11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-Acetate 17-Valerate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting pharmaceutical-grade specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.