Description

Pregna-1,4-Diene-3,20-Dione, 11-Hydroxy-16-Methyl-17,21-Bis(1-Oxopropoxy)-, (11β,16β)- is a high-purity synthetic corticosteroid derivative, a key intermediate in the production of advanced pharmaceutical actives. This compound matters for its critical role in the synthesis of potent anti-inflammatory and immunosuppressive medications, where precise chemical structure is paramount for biological activity. Pharmaceutical manufacturers and advanced R&D laboratories require this intermediate to develop and produce next-generation steroid-based therapies targeting a range of inflammatory and autoimmune conditions.

Application

• Pharmaceutical Intermediate: Primary use as a crucial building block in the multi-step synthesis of potent corticosteroid APIs (Active Pharmaceutical Ingredients).
• Anti-inflammatory Drug Development: Serves as a key precursor for novel glucocorticoid receptor agonists used in research and production.
• Immunosuppressant Synthesis: Utilized in manufacturing pathways for drugs designed to modulate immune system response.
• Advanced Steroid Chemistry: Employed in organic synthesis for creating structurally complex steroid analogs with targeted therapeutic profiles.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.
• Biochemical Research: Applied in academic and industrial research to study steroid hormone action and receptor binding mechanisms.

Basic Information

Item	Details
Product Name	Pregna-1,4-Diene-3,20-Dione, 11-Hydroxy-16-Methyl-17,21-Bis(1-Oxopropoxy)-, (11β,16β)-
CAS No.	71934-47-9
Molecular Formula	C28H38O8
Molecular Weight	502.60 g/mol
Synonyms	11β,16β-Dihydroxy-16-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate; 11β-Hydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate; 16β-Methyl-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-dipropionate; Betamethasone 17,21-dipropionate; Betamethasone Dipropionate (as intermediate); 9α-Fluoro-16β-methylprednisolone 17,21-dipropionate (related derivative); U-3468 (potential research code).
EINECS	Contact for details

Quality Control

Our Pregna-1,4-Diene-3,20-Dione, 11-Hydroxy-16-Methyl-17,21-Bis(1-Oxopropoxy)-, (11β,16β)- is manufactured under strict quality systems. The product undergoes rigorous analytical testing to ensure compliance with high-purity pharmaceutical intermediate standards. Identity, purity, and impurity profiles are verified using advanced techniques including HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each batch to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.