Description

5,12-Naphthacenedione, 10-(3-Amino-2,3,6-Trideoxy-.Alpha.-L-Lyxo-Hexopyranosyl)Oxy-7,8,9,10-Tetrahydro-8,11-Dihydroxy-8-(Hydroxyacetyl)-1-Methoxy-, (8S,10S)- is a complex anthracycline derivative of significant interest in advanced pharmaceutical research and development. Its intricate molecular structure makes it a valuable intermediate for the synthesis of novel therapeutic agents, particularly in oncology. This compound is primarily sought by research institutions and pharmaceutical companies engaged in the development of next-generation chemotherapeutics and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: Critical starting material or building block for the synthesis of novel anthracycline-based anticancer drugs.
• Oncology Research: Used in biochemical and pharmacological studies to investigate mechanisms of action, structure-activity relationships (SAR), and drug resistance.
• API Development: Serves as a key precursor in the development and scale-up of new Active Pharmaceutical Ingredients (APIs) with potential antitumor activity.
• Academic & Institutional Research: Utilized in university and government labs for fundamental research on DNA intercalation, topoisomerase inhibition, and cytotoxic agent design.
• Bioconjugation Studies: Employed in research focused on attaching targeting moieties (like antibodies or peptides) to enhance drug specificity and reduce side effects.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	5,12-Naphthacenedione, 10-(3-Amino-2,3,6-Trideoxy-.Alpha.-L-Lyxo-Hexopyranosyl)Oxy-7,8,9,10-Tetrahydro-8,11-Dihydroxy-8-(Hydroxyacetyl)-1-Methoxy-, (8S,10S)-
CAS No.	71800-89-0
Molecular Formula	C26H29NO11
Molecular Weight	531.51 g/mol
Synonyms	10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione; 4-Demethoxy-7-O-(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)adriamycinone; 4-Demethoxy-7-O-(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)doxorubicinone; 7-O-(2,6-Dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)adriamycinone; Idarubicin related compound; Idarubicin impurity; Anthracycline derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 5,12-Naphthacenedione derivative is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with ICH guidelines for impurities and can provide material meeting specific research-grade specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 1.0% Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.