Description

2-Propenenitrile,3-(4-Fluorophenyl)-,(2Z)-(9Ci) is a specialized fluorinated acrylonitrile derivative, a key building block in advanced organic synthesis. This high-purity intermediate is critical for the development of novel active pharmaceutical ingredients (APIs) and functional materials. It is primarily required by research and development laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical sectors seeking to incorporate a fluorinated phenylacrylonitrile moiety into their target molecules.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and stability.
• Liquid Crystal & OLED Material Research: Acts as a key monomer or intermediate for creating fluorinated components in electronic display and lighting materials.
• Polymer Modification: Employed to introduce fluorinated aromatic groups into polymer backbones, altering physical properties like thermal stability and solubility.
• Chemical Biology & Proteomics: Utilized as a building block for activity-based probes and other research tools that target specific enzymes or biological pathways.
• Cross-Coupling Reactions: Functions as a substrate in palladium-catalyzed reactions (e.g., Heck, Suzuki) for constructing complex biaryl structures.

Basic Information

Product Name	2-Propenenitrile,3-(4-Fluorophenyl)-,(2Z)-(9Ci)
CAS No.	71750-12-4
Molecular Formula	C9H6FN
Molecular Weight	147.15 g/mol
Synonyms	(Z)-3-(4-Fluorophenyl)acrylonitrile; (Z)-4-Fluorocinnamonitrile; (2Z)-3-(4-Fluorophenyl)prop-2-enenitrile; 3-(4-Fluorophenyl)-2-propenenitrile, (Z)-; trans-3-(4-Fluorophenyl)acrylonitrile (common mislabeling); 4-Fluoro-(Z)-cinnamonitrile; p-Fluoro-(Z)-cinnamontrile
EINECS	Contact for details

Quality Control

Our production of 2-Propenenitrile,3-(4-Fluorophenyl)-,(2Z)-(9Ci) adheres to stringent quality management protocols. Each batch is characterized and purified to meet exacting R&D and cGMP starting material standards, with purity typically exceeding 97% (by HPLC). Identity is confirmed via FT-IR, NMR (1H, 13C), and mass spectrometry. Comprehensive Certificates of Analysis (COA) detailing assay, isomeric purity (Z/E ratio), and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere to prevent degradation. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (Z-isomer)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.