Description

2,5-Difluorobenzoylacetonitrile is a versatile fluorinated aromatic building block with significant utility in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms and the reactive nitrile and carbonyl groups, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and pesticides, where the difluoro-substitution enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated organic compounds for electronic materials, liquid crystals, and advanced polymers.
• Chemical Biology Probes: Utilized to build fluorinated analogs of bioactive molecules for metabolic and mechanistic studies.
• Custom Synthesis & Contract Manufacturing: A critical raw material for fine chemical companies offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	2,5-Difluorobenzoylacetonitrile
CAS No.	71682-96-7
Molecular Formula	C10H5F2NO
Molecular Weight	193.15 g/mol
Synonyms	2,5-Difluoro-ω-cyanacetophenone; 3-Oxo-3-(2,5-difluorophenyl)propanenitrile; 1-(2,5-Difluorophenyl)-3-oxopropanenitrile; 2,5-Difluorobenzoyl methyl cyanide; (2,5-Difluorobenzoyl)acetonitrile; 3-(2,5-Difluorophenyl)-3-oxopropanenitrile; β-Oxo-2,5-difluorobenzene propanenitrile
EINECS	Contact for details

Quality Control

Our 2,5-Difluorobenzoylacetonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting all specifications are provided with every shipment. We support compliance with cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.