Description

Bisantrene Dihydrochloride is a synthetic anthracenedione derivative, recognized for its potent biological activity. This compound is a critical intermediate and active pharmaceutical ingredient (API) in advanced oncology research and development. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions focused on developing novel chemotherapeutic agents and studying mechanisms of action against resistant cancer cell lines.

Application

• Pharmaceutical API Intermediate: Serves as a key building block in the synthesis of investigational anti-cancer drugs.
• Oncology Research: Used in in vitro and in vivo studies to evaluate efficacy against various cancer types, including leukemia and solid tumors.
• Mechanism of Action Studies: Employed to investigate DNA intercalation and topoisomerase II inhibition pathways.
• Biochemical Reagent: Functions as a standard or reference compound in high-throughput screening (HTS) assays and pharmacokinetic studies.
• Drug Formulation Development: Used in pre-formulation studies for stability testing and dosage form development.

Basic Information

Product Name	Bisantrene Dihydrochloride
CAS No.	71439-68-4
Molecular Formula	C₂₆H₂₈N₄O₂ • 2HCl
Molecular Weight	509.45 g/mol
Synonyms	9,10-Anthracenedione, 1,4-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-; dihydrochloride; CL 216,942; NSC 337766; Bisantrene HCl; 1,4-Bis({2-[(2-hydroxyethyl)amino]ethyl}amino)anthracene-9,10-dione dihydrochloride
EINECS	Contact for details

Quality Control

Our Bisantrene Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation (IR, NMR). We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.