Description

n-Palmitoyldaunorubicin is a lipophilic prodrug derivative of the anthracycline antibiotic daunorubicin, where a palmitoyl group is conjugated to the sugar moiety. This structural modification is designed to enhance cellular uptake and alter the pharmacokinetic profile, potentially improving therapeutic efficacy and reducing systemic toxicity. It is a critical intermediate and research chemical for pharmaceutical development, particularly in oncology for creating novel targeted chemotherapeutic agents. Researchers and developers in advanced drug delivery and anticancer formulation rely on this high-purity compound for preclinical and process development studies.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel liposomal and nanoparticle-based chemotherapeutic agents.
• Anticancer Prodrug Development: Used in studies to create prodrugs with enhanced tumor targeting and reduced cardiotoxicity compared to parent compounds.
• Drug Delivery System Studies: Employed in research on lipid-conjugated drug carriers to improve solubility, stability, and cellular membrane penetration.
• Biochemical Mechanism Studies: Serves as a tool compound for investigating the structure-activity relationships (SAR) of anthracycline derivatives.
• Process Chemistry & Scale-up: Used as a reference standard and starting material in the development and validation of Good Manufacturing Practice (GMP) synthesis routes.

Basic Information

Product Name	n-Palmitoyldaunorubicin
CAS No.	70655-78-6
Molecular Formula	C₄₇H₆₇NO₁₅
Molecular Weight	886.03 g/mol
Synonyms	Daunorubicin 3'-(hexadecanoate); Daunorubicin palmitate; 3'-O-Palmitoyldaunorubicin; N-Palmitoyl-daunorubicin; Palmitoyl Daunorubicin; L-Palmitoyldaunorubicin; Daunorubicin 3'-palmitate; RP-60137A
EINECS	Contact for details

Quality Control

Our n-Palmitoyldaunorubicin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.