Description

Bucindolol CAS NO 70369-47-0 is a non-selective β-adrenergic receptor antagonist with intrinsic sympathomimetic activity. This compound is of significant interest in pharmaceutical research and development, particularly for its potential cardiovascular applications. It is primarily utilized by research institutions, pharmaceutical manufacturers, and contract development organizations engaged in the synthesis of novel therapeutic agents and the study of adrenergic receptor pharmacology.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced β-blocker drug candidates and related pharmacologically active molecules.
• Biochemical Research: Used as a reference standard and tool compound in studies investigating β-adrenergic receptor function, selectivity, and signaling pathways.
• Preclinical Development: Employed in the formulation and testing stages for potential new therapeutic entities targeting hypertension, heart failure, and arrhythmias.
• Analytical Standard: Serves as a high-purity calibrant for quality control laboratories performing HPLC, LC-MS, or NMR analysis of related substances.

Basic Information

Product Name	Bucindolol
CAS No.	70369-47-0
Molecular Formula	C22H32N2O3
Molecular Weight	372.50 g/mol
Synonyms	Bucindolol Hydrochloride (common salt form); 2-[2-Hydroxy-3-[[2-(3-indolyl)-1,1-dimethylethyl]amino]propoxy]benzonitrile; MJ 13105; DL-Bucindolol; (±)-Bucindolol
EINECS	Contact for details

Quality Control

Our Bucindolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing results from tests such as HPLC assay, related substances, residual solvents, and identification. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.